Gentamicin sulfate salt

Application.
Gentamicin sulfate is a broad-spectrum antibiotic, which has been used as a screening agent (gentamicin resistance gene) in cell culture and molecular biology. The recommended concentration of this product is 50mg/L.

Manual and Application.
Solubility: soluble in water, almost insoluble in ethanol.

module.
Gentamicin is an aminoglycoside complex produced by Micromonospora purpurea or Echinococcus spp. Commonly used in sulfate form. There are three ingredients, each of which consists of five basic nitrogen and requires five equivalents of sulfuric acid per molar of gentamicin.

Biochemical / physiological behavior.
Mode of action: gentamicin binds to 30s ribosomal subunit, which causes codon misreading and hinders the transfer of peptidyl transferase from donor site to receptor site. The germicidal effect of gentamicin on Pseudomonas aeruginosa is achieved through the combination of gentamicin and outer membrane to replace natural cations, making the membrane unstable and forming pores on the cell surface. Mode of action: gentamicin binds to 30s ribosomal subunit, which causes codon misreading and hinders the transfer of peptidyl transferase from donor site to receptor site. The germicidal effect of gentamicin on Pseudomonas aeruginosa is achieved through the combination of gentamicin and outer membrane to replace natural cations, making the membrane unstable and forming pores on the cell surface. Antimicrobial spectrum: includes resistance to tetracycline, chloramphenicol, kanamycin and colistin, certain Pseudomonas strains, Proteus, Staphylococcus and Streptococcus.

General description.
Gentamicin, also known as gentamicin C, is an aminoglycoside antibiotic that is naturally produced by Gram-negative bacteria. The effect of this antibiotic is to block protein synthesis. Gentamicin sulfate can inhibit the growth of Gram-positive and Gram-negative bacteria in vivo and in vitro. Gentamicin sulfate is used to inhibit the growth of various mycoplasmas in tissue culture.

Warning.
The aseptic solution should be stored at 2-8 °C. The solution is stable at room temperature and in boiling water solution of pH2-14.