Temozolomide
Braveds
Description
| Product Name | Temozolomide |
| Types | S homologous reagent |
| Form | powder |
| CAS NO | 85622-93-1 |
| Producer | China |
| Purity | >=98% (HPLC) |
| Storage | 2-8°C |
| Synonyms |
Overview
| Dissolubility | H2O: insoluble |
| Dissolubility | DMSO: soluble10 mg/mL, clear |
| Color | white to light brown |
| Content | >=98% (HPLC) |
| Form | powder |
| Storage | 2-8°C |
Application.
Temozolomide has been used to analyze the mechanism of drug resistance in glioblastoma cell lines.
Biochemical / physiological behavior.
Temozolomide is a DNA methylating agent and drug resistance modifier; anti-tumor and anti-angiogenesis. Temozolomide induces blockade and apoptosis of G2shock M through the adduction of a methyl group in genomic DNA to the O6 site of guanine and the functional inactivation of DNA repair protein O (6)-alkylguanine DNA alkyltransferase (AGT) in the base excision repair (BER) pathway.
Points for attention in preparation.
Temozolomide dissolves in DMSO with a dissolved concentration of more than 20 mg/ml. The product is insoluble in water.
Add to cart
| SKU | UNIT | PRICE (USD) | QTY |
|---|---|---|---|
| SG61529-25MG | 25MG | 35.7 | |
| SG61529-100MG | 100MG | 100.7 |
