Sodium orthovanadate

Biochemical / physiological behavior.
Inhibit ATP, alkaline phosphatase and tyrosine phosphatase. Decavanadate formed under acidic pH value can inhibit the release of Ca2+ from endocrine cells induced by inositol-1 and 5-triphosphate (IP3)-and prevent the binding of IP3 to its receptor in brain tissue.

Sodium orthovanadate inhibits the activation of p53-mediated apoptosis triggered by radiation. It reduces the adverse effects of hematopoietic syndrome, hematopoietic disturbance and delayed genotoxicity caused by whole body irradiation in mice. In combination with menadione, orthovanadate can prevent exfoliated human glioma cells from migrating due to anticancer drugs.

Application.
Sodium orthovanadate was used to prepare terminating solution in the dephosphorylation test of insulin receptor kinase. It is one of the reagents for the development of matrix chips using surface immobilized antibodies.