Streptozocin
Braveds
Description
| Product Name | Streptozocin |
| Types | S homologous reagent |
| Form | powder |
| CAS NO | 18883-66-4 |
| Producer | China |
| Purity | >=75% alpha-anomer basis, >=98% (HPLC), powder |
| Storage | -20°C |
| Recertification | 4Years |
| Synonyms |
Overview
| Storage | -20°C |
| Content | >=98% (HPLC) |
| Content | >=75% alpha-anomer basis |
| Color | white to light yellow |
| Mechanism | DNA synthesis | interferes |
| Melting point | 121°C (dec.)(lit.) |
| Form | powder |
Biochemical / physiological behavior.
A compound containing N-nitroso that acts as a donor of nitric oxide in islets; induces the death of insulin-secreting cells and produces an animal model of diabetes. Effective DNA methylating agent can induce chromosome breakage. It has cytotoxicity to neuroendocrine tumor cell lines expressing GLUT2 glucose transporter.
Application.
Streptozotocin is used to induce type 1 diabetes for medical research.
Other considerations.
Mixed isomer.
General description.
Streptozotocin, a glucosamine-nitrosourea, is a DNA alkylating agent that enters cells only through GLUT2 glucose transporters. Streptozotocin is particularly harmful to beta cells that produce islet insulin. It is toxic to GLUT2 positive neuroendocrine tumor cells.
Add to cart
| SKU | UNIT | PRICE (USD) | QTY |
|---|---|---|---|
| SG18935-100MG | 100MG | 76.3 | |
| SG18935-500MG | 500MG | 149.8 | |
| SG18935-1G | 1G | 223.8 |
