L-NAME|Nω-Nitro-L-arginine methyl ester hydrochloride

Biochemical / physiological behavior.
An arginine analogue that inhibits the production of NO. It has multiple effects on the vascular system. It inhibits the relaxation caused by acetylcholine and increases arterial blood pressure. When pretreated with the preparation of aortic ring in mice, the vasodilation induced by lecithin superoxide dismutase could be abolished. Induce leukocyte adhesion and increase the flux and permeability of microvascular fluid and protein. It is also used in many studies related to learning and memory.