(Z)-4-Hydroxytamoxifen

Storage conditions are dry and avoid light.
Storage temperature 2-8 °C.
Soluble methanol: 10 mg/mL; ethanol: 20 mg/mL (heating).

Biochemical / physiological behavior.
4-hydroxytamoxifen (4-OHT) is an active metabolite of tamoxifen, which combines estrogen receptor (ER) and estrogen-related receptor (ERR) to produce estrogenic and antiestrogenic effects. It is a selective estrogen receptor modulator (SERM) that can be permeated by cells. In the genetic engineering of Cas9 variants of ligand-dependent introns, 4-hydroxytamoxifen is used to control the Cas9 function that weakens the targeting effect in CRISPR-mediated gene editing.