(S)-(+)-Camptothecin
Braveds
Description
| Product Name | (S)-(+)-Camptothecin |
| Types | S homologous reagent |
| Form | powder |
| CAS NO | 3/4/7689 |
| Producer | China |
| Purity | >=90% (HPLC), powder |
| Storage | 2-8°C |
| Synonyms |
Overview
| Mechanism | enzyme | inhibits |
| Mechanism | DNA synthesis | interferes |
| Storage | 2-8°C |
| Melting point | 260°C (dec.)(lit.) |
| Dissolubility | chloroform/methanol (4:1): soluble5 mg/mL |
| Form | powder |
| Content | >=90% (HPLC) |
| Gene information |
human ... TOP1(7150)mouse ... Prkca(18750)rat ... Sstr2(54305) |
Biochemical / physiological behavior.
(s)-(+)-camptothecin irreversibly binds to DNA- topoisomerase I complex, inhibits the rebinding of DNA after topoisomerase I cleavage, and immobilized the enzyme by covalent binding with DNA. The enzyme complex was ubiquitinated and destroyed by 26S proteasome, thus depleting cell topoisomerase I. Low dose of s-camptothecin can block the cell cycle in S phase and induce apoptosis of a large number of normal cells and tumor cell lines in a cycle-dependent and independent manner.
Other considerations.
20S isomer
Add to cart
| SKU | UNIT | PRICE (USD) | QTY |
|---|---|---|---|
| SG03332-100MG | 100MG | 107 | |
| SG03332-1G | 1G | 165.3 |
