Acetyl coenzyme A sodium salt

Application.
Acetyl-CoA is the main cofactor and carrier of acyl group in enzymatic acetyl transfer reaction. It is formed by oxidative decarboxylation of pyruvate in mitochondria, oxidation of long-chain fatty acids or oxidative degradation of some amino acids. Acetyl-CoA is the initial compound of tricarboxylic acid cycle (Kreb's cycle). It is also a key precursor of lipid biosynthesis and a source of all fatty acid carbon. Acetyl-CoA regulates the activity of pyruvate carboxylase. It is the precursor of the neurotransmitter acetylcholine. Histone acetyltransferase (HAT) uses acetyl-CoA as an acetyl donor for post-translational acetylation of histone and non-histone.

An important cofactor of enzymatic acetyl transfer reaction.

Biochemical / physiological behavior.
Acetyl-CoA is a necessary cofactor and carrier of acyl group in enzymatic acetyl transfer reaction. It can be formed by oxidative decarboxylation of pyruvate in mitochondria, oxidation of long-chain fatty acids or oxidative degradation of some specific amino acids. Acetyl-CoA is the initial compound of the citric acid cycle (Kreb cycle). It is also a key precursor of lipid biosynthesis and a source of all fatty acid carbon. Acetyl-CoA can positively regulate the activity of pyruvate carboxylase. It is the precursor of the neurotransmitter acetylcholine. Histone acetylase (HAT) uses acetyl-CoA as an acetyl donor for post-translational acetylation of histone and non-histone proteins.

Points for attention in preparation.
Preparation with enzyme